Primordial germ cell (PGC) specification occurs early in development.PGC specifiers have been identified in Drosophila, mouse, and human but remained elusive in most animals.Here we identify Space Art the RNA-binding protein Dnd as a critical PGC specifier in the medaka fish (Oryzias latipes).Dnd depletion specifically abolished PGCs, and its overe
Angiopoietin-like (ANGPTL)3 and ANGPTL8 are secreted proteins and inhibitors of LPL-mediated plasma triglyceride (TG) clearance.It is unclear how these two ANGPTL proteins interact to regulate LPL activity.ANGPTL3 inhibits LPL activity and increases serum TG independent of ANGPTL8.These effects are reversed with an ANGPTL3 blocking antibody.Here, w
The Nilgiri Mystus, Hemibagrus punctatus, a rare bagrid catfish endemic DEODORANT SPORT to the Western Ghats, has been currently listed in the IUCN Red List, as Critically Endangered with a possibility that it could be extinct.The last validated record of H.punctatus was known to be in 1998, and several surveys since then have not been able to coll